Drifts over time are a thorny problem in CGMs, no matter it is electrochemical (enzymatic or non-enzymatic) or optical. The exist of instability results in short life time and requires frequent calibration from figure stick, which contributes the high cost of CMG products and the reluctance to use in diabetic patients. A platform that has two sensing mechanisms for glucose sensing shall provide the basis for self-calibration and self-correction. Together with our new developed diboronic acid (DBA+), a molecule, alizarin red S (ARS) that has favorable optical property, electrochemical response and the ability to reversibly bind with boronic acid, is thus introduced and developed for this kind of dual-sensor. The fluorescence of ARS exhibits more than 10 times enhancement in the presence of DBA+. The fluorescence decreases with the increase of glucose concentration, due to the competitive binding with glucose. ARS redox peaks also decreases after binding with DBA+, and can be recovered by glucose. The basis of dual-mode glucose sensing in one system was demonstrated, and the self-calibration using both electrochemical and optical signals is expected to afford a long-term stable glucose monitor.