Research

Boronic acids (BAs) can form reversible covalent linkages to 1,2- and 1,3-diols which in particular present in sugars. In the process of binding diols, BAs become considerably more acidic, with pKa decreases of 2-4 units. The binding-induced change in BA acidity can induce changes in solution pH, electrostatic interactions and surface charge. These properties may ultimately be useful for optical, conductimetric, and field-effect transistor-based glucose sensing. However, mono BAs (MBAs) show higher affinity to other interferential sugars in blood than glucose.

Drifts over time are a thorny problem in CGMs, no matter it is electrochemical (enzymatic or non-enzymatic) or optical. The exist of instability results in short life time and requires frequent calibration from figure stick, which contributes the high cost of CMG products and the reluctance to use in diabetic patients. A platform that has two sensing mechanisms for glucose sensing shall provide the basis for self-calibration and self-correction.